The milling speed affects its surface integrity whenTB6 titanium alloy is being machined. The experimental results show that the surface roughness decreases first and then increases, the work hardening increases, and the residual stress value decreases respectively with the increase of milling speed when the cutting is at a low speed from 20 to 60 m/min; And the surface roughness, the work hardening and the residual stress value decrease respectively when cutting is at a high speed from 100 to 300 m/min. With the depth of residual stress profile being “spoon” pattern, the deposited materials or the pitting corrosions are observed on machined surface samples.