Nonionic poly-N-isopropylacrylamide (PNIPAM) and anionic poly(N-isopropyl-acrylamide-co-methacrylic acid) (P(NIPAM-co-MAA)) micro-gels containing Cd2+ are prepared by employing inverse suspension polymerization method. PNIPAM/CdS and P(NIPAM-co- MAA)/CdS composite micro-spheres with patterned surface structures are prepared by using micro-gels as micro-reactors and templates and inputting H2S gas slowly to confine and direct the precipitation of CdS. The surface morphologies of the composite micro-spheres depend upon the composition of the templates. SEM measurements indicated that the micro-spheres prepared are about 50 μm and occupy pursued core-shell structures. XRD indicated CdS precipitated within/on the template is in a crystalline state, and belongs to cubic crystalline system. Fluorescence measurements indicate that the emission of the micro-spheres is characterized by CdS, and the emission is slightly affected by the composition of the template employed.