The vehicle schedule model in flight supporting process is established, and an optimized algorithm of vehicle resource arrangement based on Tabu Search algorithm is proposed. The simulation model and the optimized algorithm are integrated through built-in VBA technique and VBA block of Arena, which makes up the vehicle schedule simulation-based optimization system. The simulation-based optimization system realized three functions: controlling simulation model, integrating optimization algorithm and inputting parameters into simulation model. Through this system, the optimum vehicle number arrangement under minimum single flight support time is obtained. The operation efficiency is increased by more than 7 times by using this system than by using the bound optimized tools OptQuest for Arena.