To improve the performance of the adaptive scene -based technology for non-uniformity correction, an adaptive non-uniformity correction technology for infrared focal plane arrays based on pre-processing with median filter is proposed. The proposed algorithm has been tested with the video sequences of simulated and real infrared data, reaching high correction levels, reducing the fixed pattern noise and preserving image details. The algorithm has low computational complexity and can obtain an efficient frame by frame adaptive estimation of detector's gain and offset.