In this paper, the multidisciplinary aerodynamic-structure optimization design method of elastic wing based on response surface methodology was performed.M6 wing was choosed as the base wing. The design results show that lift-to-drag ratio was increased 9.25% and structural weight was reduced 4.84%，response surface methodology was accurate enough to satisfy the engineering requirement. It can be concluded that the present method is effective and feasible, and is very attractive for engineering application due to its high design capability.