In order to attenuate interference with the hypersonic vehicle head shocks and flank front shocks, a simulation model on plasma high-energy synthetic jet shock-shock interference control is established. The flow field characteristics of the shock-shock interference control of plasma high-energy synthetic jet waves are analyzed, the effect of plasma high-energy synthetic jet for shock-shock interference control is explored, and the parameters of the control effect are studied for the installation position and the energy size of the actuator. The results show that the bow shock generated by the high plasma energy synthetic jet enables the head shock to lift a certain angle, reducing head shock to flank leading shock disturbance, and control the effect of heat flow and pressure in the shock-shock interference area. With increase of exit distance, the control effect of heat flow and pressure increases first and then decreases. Within a certain range, the higher the energy applies, the better the control effect.