In view of realizing an advanced power plant by using aviation kerosene to meet the needs of regenerative cooling, a threedimensional numerical model of fluidthermalstructural coupling in the rectangular cooling channel is established, and the influence of working conditions, such as inlet flow mass rate, pressure and heat flux density on the flow and heat transfer characteristics of aviation kerosene in the rectangular cooling channel is analyzed. The results show that increasing the mass flow rate and reducing the heat flux density will definitely enhance the heat transfer ability of aviation kerosene. Within the range of a certain pressure, the influence of pressure on aviation kerosene heat transfer is not obvious, but with the increase of pressure, the heat transfer ability of aviation kerosene becomes worse. Due to the occurrence of heat transfer deterioration, the influence of the working conditions as mentioned above on the pressure loss and the friction resistance is comparatively complicated