A creep thermal fatigue life prediction method for an accessory shell based on the coupling of thermosetting vibration is proposed in this paper. The distribution of the temperature filed of the accessory shell obtained by the ANSYSFluent module is based on the simulation results of the fluid solid heat coupling, and the results are verified by the measured data. The stress and strain field of the shell is obtained by using the temperature field data transfer approach and the ANSYSWorkbench module to simulate the thermal solid vibration coupling of the accessory shell, and coupled with the linear cumulative damage theory, the creep rupture life and thermal fatigue life of the accessory shell are coupled, obtaining the creep thermal fatigue life prediction results. On the one hand, the differences between pure thermal fatigue life (41 063 cycle life) and creep thermal fatigue life (39 054 cycle life) are compared and analyzed. The results show that the high thermal creep in the aero engine accessory system has a significant effect on the thermal fatigue life of the accessory shell. On the other hand, the creep thermal fatigue (23 334 cycle life) based on steadystate temperature field and the creep thermal fatigue (24 545 cycle life) based on transient temperature field (considering temperature and variable rate) are compared and analyzed. The results show that the temperature change rate affects the creep thermal fatigue life in the aero engine accessory system to a certain extent.