To solve the problem of gain error and timing-skew mismatches among channels of time-interleaved analog-to-digital converter（TIADC）system, a joint measurement method of mismatches error is proposed. By making full use of the characteristic of the test signal, this method can measure two kinds of errors simultaneously. Compared with the existing algorithm, the measurement algorithm is simple and more effective. According to the principle of timing-skew, the compensation method of fractional delayed filter based on Farrow structure is designed. Because of the problem of limited Nyquist bandwidth of Farrow structure, a multi-channel compensation structure is designed. After compensation, the output SINAD of the system is increased by at least 25dB.