A novel compact Single-Feed Dual-Frequency Patch Antenna is proposed in this paper. According to the analyses of characteristics of two operation bands, monolayer micro-strip-fed and slot-rectangle frame are adopted and separately printed on the opposite side of substrate in this antenna. The area of this antenna is only 20×26 mm. The operation bands of the antenna are from 2.40 GHz to 2.53 GHz and from 5.00 GHz to 5.96 GHz. Simultaneously the parameters that affect the operation frequencies are analyzed and studied by using EM simulation software HFSS10. Lastly, the antenna is fabricated and measured, and the measured results are in good agreement with the simulated results. The antenna proposed in this paper has the characteristics of miniaturization and dual-band, so it is suited for wireless communication field.