Ergonomics optimization design of keys around screen in helicopter cockpit is meaningful to the improvement of operating performance, but the research on its ergonomics characteristics in a vibration environment is a weak link. In this article, we take a new method to investigate this problem with a simulation platform. Through data analyses, some results are summed up as follows. The response time is affected by key size and its position. That the key size is 10 mm is preferable without vibration. And that it is 13 mm, or 25% bigger, in other words, is preferable with the vibration of 23 Hz which can be felt slightly by human body. Under vibration, it is appropriate that the interval between keys is 10 mm. The increase of mistakes and response time caused by vibration must be under suitable control. The result of this research is of some reference value to the ergonomics design and improvements of helicopter manipulating performance.