A terminal guidance law based on the terminal sliding mode technology is proposed for the precise interception of exo-atmospheric kinetic interceptor. Firstly, the longitudinal and lateral equations of relative motion are built without considering the kinetic interceptor's attitude motion. Then the nonlinear terms are introduced into the mode designing of terminal guidance law, so this terminal guidance law doesn't have the switch terms that exist in the traditional variable structure guidance law and can ensure the global speediness of guidance system. The simulation results show that the method used in the terminal guidance of kinetic interceptor is effective and it's better than the proportional navigation and traditional variable structure guidance law in robustness and precision when intercepting the maneuvering targets.